MALAT1 ASO
Molecular target
A long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is among the most conserved lncRNAs and is highly abundant in most normal tissues. MALAT1 has been shown to regulate gene expression, transcriptionally regulating motility related genes that influence metastases.
| mRNA target | Species | Tool | Sequence 5’-3’ (AZ) | 5’ Modification | 3’ Modification | PO or PS to linker | Backbone | Design (PO/PS) |
|---|---|---|---|---|---|---|---|---|
| MALAT1 | Mouse/human | ASO | GmCA TTmCTAATAGmC AGmC | No | No | N/A | PS | 3-10-3 LNA-DNA-LNA |
| HA-MALAT1 | Mouse/human | ASO | 5'-HA-GmCA TTmCTAATAGmC AGmC | C6 amino | No | PS | PS | 3-10-3 LNA-DNA-LNA |
| Random Negative Control | ASO | GGmC mCAATAmCGmCmCG TmCA | No | No | N/A | PS | 3-10-3 LNA-DNA-LNA | |
| HA-Random Negative Control | ASO | 5'-HA-GGmC mCAATAmCGmCmCG TmCA | C6 amino | No | PS | PS | 3-10-3 LNA-DNA-LNA |