PPIB siRNA
Molecular target
Peptidyl-prolyl cis-trans isomerase B (PPBI) is an enzyme that catalyzes cis-trans isomerization to accelerate protein folding in various cellular processes including the immune response and cell cycle regulation.
| mRNA target | Tool | Sequence 5’-3’ (AZ) | 5’ Modification | 3’ Modification | PO or PS to linker | Backbone | Design (PO/PS) |
| PPIB (guide) antisense | siRNA | P(mU)*(fC)*(mA)(fC)(mG)(fA)(mU)(fG)(mG)(fA)(mA)(fU)(mU)(fU)(mG)(fC)(mU)(fG)*(mU)*(fU) | Phosphate | No | 2*PS at each end | PO/PS | Alt F/OMe |
| PPIB (passenger) sense | siRNA | (mC)*(fA)*(mG)(fC)(mA)(fA)(mA)(fU)(mU)(fC)(mC)(fA)(mU)(fC)(mG)(fU)*(mG)*(fA) | No | No | 2*PS at each end | PO/PS | Alt F/OMe |
| PPIB (passenger) sense NH2 | siRNA | (mC)*(fA)*(mG)(fC)(mA)(fA)(mA)(fU)(mU)(fC)(mC)(fA)(mU)(fC)(mG)(fU)*(mG)*(fA)-AMO | No | Amine | 2*PS at each end | PO/PS | Alt F/OMe |
| NTA (guide) antisense | siRNA | P(mU)*(fA)*(mA)(fU)(mC)(fG)(mU)(fA)(mU)(fU)(mU)(fG)(mU)(fC)(mA)(fA)(mU)(fC)*(mA)*(fU) | Phosphate | No | 2*PS at each end | PO/PS | Alt F/OMe |
| NTC (passenger) siRNA sense | siRNA | (mG)*(fA)*(mU)(fU)(mG)(fA)(mC)(fA)(mA)(fA)(mU)(fA)(mC)(fG)(mA)(fU)*(mU)*(fA) | No | No | 2*PS at each end | PO/PS | Alt F/OMe |
| NTC (passenger) siRNA sense NH2 | siRNA | (mG)*(fA)*(mU)(fU)(mG)(fA)(mC)(fA)(mA)(fA)(mU)(fA)(mC)(fG)(mA)(fU)*(mU)*(fA)-AMO | No | Amine | 2*PS at each end | PO/PS | Alt F/OMe |