Drug delivery
Innovate drug delivery technologies for next generation therapeutics
Identifying new approaches for effective drug delivery
Many future scientific breakthroughs will result from the development of new drug delivery technologies and the ability to target previously undruggable disease targets with new therapeutic modalities. This is why we are investing in diverse drug platforms and expanding our toolkit of drug delivery technologies. Our aim is to design therapeutics for disease mechanisms previously considered difficult, if not impossible, to target and enable our scientists to pioneer new approaches to drug discovery. We want to partner with you to realise our goal of effectively delivering new modalities such as nucleic acids, peptides and other macromolecules.
Programme details
Submission status: Active
No submission deadline, please apply any time.
We are looking to collaborate with academic researchers and institutional research centres working on novel, innovative drug delivery systems and drug development platforms across a range of advanced modalities. This includes nanoparticle-based systems, targeted therapeutics, and complex formulation technologies.
- Collapse all
- Develop advanced bioconjugation strategies and scalable surface functionalization methods for targeted Nanoparticles, focusing on: Site-specific conjugation techniques for a diverse range of targeting ligands, including Fab fragments, VHHs (camelid single-domain antibodies), Aptamers, Peptides, Antibodies and Small molecule targeting agents.
- Orthogonal coupling methods for multi-ligand functionalization.
- Controlled ligand density and spatial distribution optimization.
- Advanced Structural Analysis of Complex Conjugates at Single-Particle Level: Advanced analytical tools and imaging methodologies to understand the intricate details of individual nanoparticles, moving beyond bulk measurements. The goal is to accurately quantify ligand density and ligand distribution.
- Accelerated Testing and Characterization for Advanced Drug Delivery Systems: Integrating high-throughput screenings in stability testing and biorelevant assessment. Leveraging modelling and machine learning to predict nanoparticle stability data, and to correlate in vitro stability with in vivo performance, thereby enabling faster and more reliable characterization.
- Advanced specialized delivery systems and controlled release technologies for precise targeting of organs such as the lung, skeletal muscle, heart and colon, optimize alternative administration routes like nose-to-brain and mucosal pathways, and design novel formulation strategies for localized gastrointestinal delivery to enhance therapeutic index and minimize systemic exposure.
- Developed next-generation excipients and formulation technologies to enable effective oral, subcutaneous, and high-concentration delivery of difficult-to-formulate molecules, such as poorly soluble small molecules, PROTACs and peptides, with a focus on overcoming bioavailability, permeability, solubility and viscosity challenges.
Loading......