Clinical Compound Bank
Access our patient-ready compounds with evidence of human target coverage and manageable tolerability.
Access compounds with optimised pharmacological properties for preclinical research to study pathways and mechanisms of disease biology.
Have a novel target idea or assay for a drug discovery project? Our diverse High Throughput Screening (HTS) compound library may help you advance or validate your idea.
New Molecule Profiling
Explore the properties and therapeutic potential of your novel compounds by leveraging our cheminformatic and screening technologies.
Offer and be rewarded for your innovative ideas and research expertise to help overcome difficult R&D barriers.
Do you have an idea, technology or suggestion outside of these categories? We are still welcoming proposals, so please get in touch.
Leading the Way in Open Innovation
clinical and preclinical projects in progress
compounds available from our screening library
R&D Challenges awarded to date
Why collaborate through Open Innovation?
Beyond the usual research partnerships – let's push the boundaries of science together
AstraZeneca has spent decades creating unique enabling tools and technologies of interest to the scientific community of investigators. These include optimised compounds with extensive data packages, high throughput screening libraries and facilities, cheminformatics and other in silico analytics, and drug R&D knowhow, expertise and experience. At the same time, academic, research foundation and biotech investigators have been developing insights, tools, technologies, platforms, resources and facilities that complement those of AstraZeneca. Examples include disease pathophysiology and patient care insights, assay, biomarker and imaging technologies, and specialised facilities.
By bringing all of this together through partnering, we can test hypotheses that may otherwise not be possible. Sharing ideas and enabling scientific innovation to cross boundaries between academia, industry, government and non-profit organisations will help us translate innovative ideas into scientific breakthroughs and potential new medicines more quickly and effectively.
At AstraZeneca, we have great scientists doing truly ground-breaking research. But in order to speed up the delivery of the next generation of medicines, we also need to access the best science outside our labs. We are always looking for new ways of working with academic or industry researchers who share our passion for advancing the science and helping patients with unmet medical needs.
In 2011, a novel agreement between the Medical Research Council (MRC) and AstraZeneca gave academic researchers across the UK unprecedented access to 22 of our clinical and preclinical compounds.
These compounds had stalled in early testing, often because they didn’t prove effective against the original target. But they may still be useful against other diseases. And because the compounds have already undergone some preliminary development, any new treatments arising from the research could reach patients faster. Fifteen studies are currently underway covering respiratory illness, muscular dystrophies, bone disease and various mental health conditions.
Latest Partnering news
AstraZeneca featured news
Professor David Goldstein to lead AstraZeneca’s genomics initiative as Chief Adviser
AstraZeneca is pleased to announce that Professor David Goldstein will join the Company in the consultative role of Chief Adviser, Genomics to lead its integrated genomics initiative, which was announced in April. This 10-year initiative will focus on the discovery of new targets and biomarkers linked to molecular mechanisms of disease across AstraZeneca’s main therapy areas. Professor Goldstein will continue in his full-time role as Director of the Institute for Genomic Medicine, John E. Borne Professor and Professor of Genetics and Development at Columbia University Medical Center. He is renowned for his research on human genetic diversity, the genetics of disease and pharmacogenetics and will be responsible for driving the scientific progress of AstraZeneca’s genomics initiative, created to transform drug discovery and development across the entire research and development pipeline.
Patients at the core of partnership
Commentary by Jennie Younger, Vice President of Global Corporate Affairs, on Dr. Tony Hockley’s post on PAD (peripheral arterial disease).
Innovative pancreatic research expands treatment horizons for people with type 2 diabetes
New understanding of how hormone-producing cells in the pancreas decode their genetic instructions is pointing to novel targets for next generation medicines for type 2 diabetes, obesity and other metabolic disorders.
A large scale analysis of gene expression in individual islet cells of the pancreas suggests insulin-producing beta cells are not the only sub-class of cells important for glucose control and diabetes treatment as previously thought. The research, carried out at the AstraZeneca/ Karolinska Insitutet Integrated Cardiometabolic Center (ICMC), Stockholm, Sweden, has shown that other types of islet cells, notably alpha and delta, may also play a significant role.
A game-changing scientific collaboration: Charles River and AstraZeneca
“There are still patients out there with unmet clinical need, waiting for new medicines. That’s how important this is.” AstraZeneca and Charles River share a passion for ground-breaking scientific research. Our partnership is focused on accelerating the delivery of new medicines. Watch our video to find out more about our success to date.
Peripheral Patients? PAD (peripheral arterial disease) Policy Initiative
A guest blog post by Dr. Tony Hockley, Visiting Senior Fellow, Department of Social Policy, London School of Economics and Political Science (LSE). LSE is developing a white paper on PAD funded by and in collaboration with AstraZeneca. PAD is a disease that affects around 202 million people worldwide1 and puts a significant strain on health and economic systems yet awareness remains low and sub-optimal care is an issue.
Opening up a treasure trove of new drug target opportunities - By using novel boronic acid chemistry our scientists have generated covalent inhibitors of Mcl-1, a notoriously difficult and key target in oncology.
For the first time, scientists from our Innovative Medicines & Early Development (IMED) Biotech Unit have shown that it is possible to inhibit high value protein-protein interaction (PPIs) drug targets, such as Mcl-1, through the use of novel lysine targeting covalent warheads.